Adipocyte maturation impacts daunorubicin disposition and metabolism
Fat is an expandable tissue that can sequester and detoxify DNR when stimulated by obesity, likely through the upregulation of DNR-metabolizing enzymes AKR1C3 and CBR1. Our data partially explains why obese ALL patients may be more likely to become chemoresistant towards DNR, and provides evidence for potential clinical investigation targeting obesity to reduce DNR chemoresistance.
Authors
- Stan G. Louie (ORCID: https://orcid.org/0000-0001-5941-6690)
- Zeyang Li
- Steven D. Mittelman (ORCID: https://orcid.org/0000-0003-2867-1298)
- Kaitlyn Trinh
- Vladislava Paharkova (ORCID: https://orcid.org/0009-0001-1509-7170)
- Danh Le
- Isaac Asante (ORCID: https://orcid.org/0000-0002-9628-3425)
- Rachael Ngu
- Hua Pei
- Yulu Liu (ORCID: https://orcid.org/0000-0001-6024-1701)
- Cindy Zhuang
- Aditya Naik
- Hanyue Liao
Institutions
- University of Southern California (US)
- University of California, Los Angeles (US)
- SUNY Upstate Medical University (US)
- Mattel Children's Hospital (US)
- University of Houston (US)
- Nagoya University (JP)
Publication Details
- Journal
- European Journal of Clinical Investigation
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1111/eci.14307
- Citations
- 2
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- National Cancer Institute