Changes in 24(S)-Hydroxycholesterol Are Associated with Cognitive Performance in Early Huntington’s Disease: Data from the TRACK and ENROLL HD Cohorts
Our findings support growing evidence for dysregulated CNS cholesterol homeostasis in HD, demonstrate a relationship between changes in oxysterols and cognitive performance in HD, and propose that NMDA receptor hypofunction may contribute to cognitive impairment in HD.
Authors
- Michael C. Quirk
- Negah Rahmati (ORCID: https://orcid.org/0000-0002-0709-5976)
- Jing Dai (ORCID: https://orcid.org/0000-0002-9282-4052)
- Michael Lewis (ORCID: https://orcid.org/0000-0002-4958-6634)
- Jacob T. Beckley (ORCID: https://orcid.org/0000-0003-2950-6462)
- Sarah M. Gray (ORCID: https://orcid.org/0000-0003-2370-7968)
- Anne C. Smith
Institutions
- Sage Therapeutics (United States) (US)
Publication Details
- Journal
- Journal of Huntington s Disease
- Published
- 2024-09-10
- DOI
- https://doi.org/10.3233/jhd-240030
- Citations
- 9
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.41