Screening, identification and targeted intervention of necroptotic biomarkers of asthma
The necroptosis pathway is activated in asthma, with NRDEGs-namely PYCARD, NLRP3, ALOX15, and VDAC3-correlated with declines in lung function and airway inflammation. These genes serve as reliable predictors of asthma risk and are involved in the regulation of the immune-inflammatory microenvironment. Resveratrol and triptolide have been identified as promising therapeutic candidates due to their potential to target the proteins encoded by these genes.
Authors
- Xinyu Jia (ORCID: https://orcid.org/0000-0002-1832-9504)
- Mao Huang (ORCID: https://orcid.org/0000-0002-2743-1017)
- Yuan Ma (ORCID: https://orcid.org/0000-0002-0207-3620)
- Lan Yang (ORCID: https://orcid.org/0000-0002-5761-5052)
- Zhenzhen Wu (ORCID: https://orcid.org/0000-0001-6751-6448)
- Ling Feng
- Min Wang (ORCID: https://orcid.org/0009-0002-8756-0707)
Institutions
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1016/j.bbrc.2024.150674
- Citations
- 3
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China