Simple supplementation of serum-free medium produces gametocytes of Plasmodium falciparum that transmit to mosquitoes
Serum-free medium supplemented with ITS-X was able to support the growth of gametocytes of P. falciparum that were as infectious to An. gambiae as those grown in medium with 10% serum. This is the first fully serum-free culture system able to produce highly infectious gametocytes, thereby removing the requirement for access to serum for transmission assays.
Authors
- Prince Chigozirim Ubiaru (ORCID: https://orcid.org/0000-0003-2360-8855)
- Lisa Ranford‐Cartwright (ORCID: https://orcid.org/0000-0003-1992-3940)
- Sabyasachi Pradhan
Institutions
- University of Glasgow (GB)
Publication Details
- Journal
- Malaria Journal
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1186/s12936-024-05094-8
- Citations
- 4
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 2.17
Funders
- “la Caixa” Foundation
- Tenovus
- University of Glasgow
- Tertiary Education Trust Fund