Exosome-mediated transfer of lncRNA RP3-340B19.3 promotes the progression of breast cancer by sponging miR-4510/MORC4 axis
Our findings establish that RP3-340B19.3 plays a pivotal role in driving the proliferation and metastasis of breast cancer. Additionally, exosomes enriched in RP3-340B19.3 could influence MCF7 and BMMSCs in tumour microenvironment, promoting the progression of breast cancer. This discovery positions RP3-340B19.3 as a prospective novel candidate for a tumour marker, offering substantial potential in the realms of breast cancer diagnosis and treatment strategies.
Authors
- Linxia Wang (ORCID: https://orcid.org/0000-0001-5843-8425)
- Jiahui Mao (ORCID: https://orcid.org/0009-0007-8124-7206)
- Bo Wang (ORCID: https://orcid.org/0000-0001-5654-6617)
- Bingying Wang
- Huan Yang (ORCID: https://orcid.org/0000-0002-3106-490X)
- Yuexin Zhao
Institutions
- Jiangsu University (CN)
- Soochow University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1186/s12935-024-03490-3
- Citations
- 4
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Science and Technology Program of Suzhou