Individual analysis of fMRI data reveals incongruency in a potential CADASIL biomarker
fMRI-based studies on neurodegenerative diseases rarely report single-subject information, which is useful for assessing potential biomarkers. In a previous fMRI study, CADASIL patients showed, at the group level, a significant reduction of the long-lasting visually stimulated hyperaemic response. Here, we used data interpolation and computed a hemodynamic response function from the 20-s visual response to achieve a 40-s response prediction at the individual level. The comparison between the expected and recorded 40-s responses confirmed the occurrence of a late and frequent response reduction among patients. However, this feature was inversely related to age and was also detected in control subjects, which suggests that this potential biomarker cannot be retained for monitoring vascular dysfunction in CADASIL. We showcase an open-source analytical pipeline for single-subject analysis to quickly assess potential biomarkers in fMRI studies.
Authors
- Clément Huneau
- Ali-Kemal Aydin (ORCID: https://orcid.org/0000-0002-3583-6604)
- Davide Boido (ORCID: https://orcid.org/0000-0002-1823-0555)
- Serge Charpak (ORCID: https://orcid.org/0000-0002-5516-1245)
- Jessica Lebenberg (ORCID: https://orcid.org/0000-0002-5403-8288)
- Benoît Béranger (ORCID: https://orcid.org/0000-0003-0704-9854)
- Hugues Chabriat (ORCID: https://orcid.org/0000-0001-8436-6074)
Institutions
- École Centrale de Nantes (FR)
- Centre National de la Recherche Scientifique (FR)
- Institut de la Vision (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Sorbonne Université (FR)
- Institut des Neurosciences Paris-Saclay (FR)
- Sorbonne Paris Cité (FR)
- Hôpital Fernand-Widal (FR)
- Fondation de l'Avenir (FR)
- Laboratoire des Sciences du Numérique de Nantes (FR)
- Hôpital Lariboisière (FR)
- Hôpital Robert-Debré (FR)
- CEA Paris-Saclay (FR)
- FHU Neurovasc (FR)
- Institut du Cerveau (FR)
- NeuroDiderot (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Journal of the Neurological Sciences
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1016/j.jns.2024.123227
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche