Conditional ablation of MCU exacerbated cardiac pathology in a genetic arrhythmic model of CPVT
We present genetic evidence that mitochondria play a protective role in CPVT. MCU-dependent Ca<sup>2+</sup> uptake is crucial for preventing pathological cardiac remodeling in CPVT.
Authors
- James A. Stewart (ORCID: https://orcid.org/0000-0001-8920-8809)
- Brian D. Tow (ORCID: https://orcid.org/0000-0003-2414-0369)
- Valeria Gomez
- Arpita Deb (ORCID: https://orcid.org/0009-0003-6685-0358)
- Ashley J. Smuder (ORCID: https://orcid.org/0000-0001-5437-3097)
- Branden L. Nguyen (ORCID: https://orcid.org/0000-0002-8883-8590)
- Björn C. Knollmann (ORCID: https://orcid.org/0000-0003-4956-9735)
- Ying Wang (ORCID: https://orcid.org/0000-0002-9659-977X)
- Bin Liu (ORCID: https://orcid.org/0000-0003-2184-4723)
- Jie Hao (ORCID: https://orcid.org/0000-0002-0273-8047)
Institutions
- Vanderbilt University (US)
- University of Florida (US)
- Mississippi State University (US)
Publication Details
- Journal
- Journal of Molecular and Cellular Cardiology Plus
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1016/j.jmccpl.2024.100093
- Citations
- 1
- Primary Topic
- Cardiac Arrhythmias and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- Mississippi State University
- National Institutes of Health
- National Heart, Lung, and Blood Institute