Cafeteria diet compromises natural adaptations of islet cell transdifferentiation and turnover in pregnancy
Augmentation of β-cell mass during gestation arises through various mechanisms that include proliferation and survival of existing β-cells, transdifferentiation of ductal cells as well as β-cell neogenesis. Remarkably, cafeteria feeding almost entirely annuls pregnancy-induced islet adaptations, which may contribute to the development of gestational diabetes in the setting of dietary provoked metabolic stress.
Authors
- Nigel Irwin (ORCID: https://orcid.org/0000-0003-4855-964X)
- Vaibhav Dubey (ORCID: https://orcid.org/0000-0002-1989-2403)
- Andrei I. Tarasov (ORCID: https://orcid.org/0000-0002-8883-176X)
- R. Charlotte Moffett (ORCID: https://orcid.org/0000-0002-7196-7863)
- Peter R. Flatt (ORCID: https://orcid.org/0000-0001-8548-7943)
- Neil Tanday (ORCID: https://orcid.org/0000-0001-6525-4050)
Institutions
- University of Ulster (GB)
Publication Details
- Journal
- Diabetic Medicine
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1111/dme.15434
- Citations
- 3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Diabetes UK
- Ulster University