Total Synthesis of (−)-Zearalenone and (−)-Zearalanone: A Macrocyclization Strategy by Ni/Zr/Cr-Mediated Reductive Ketone Coupling
The total synthesis of the resorcylic acid lactones (-)-zearalenone and (-)-zearalanone is described. Our synthetic strategy relies on Ni-, Zr-, and Cr-mediated intramolecular reductive ketone coupling to create 14-membered macrolactones. Notably, the use of CrCl<sub>2</sub> in addition to Ni/Zr-mediated reductive ketone coupling conditions was key for the success of the macrocyclization.
Authors
- Atsushi Umehara (ORCID: https://orcid.org/0000-0002-3705-5078)
- Makoto Sasaki (ORCID: https://orcid.org/0000-0003-2964-7986)
- K. Kawakita
Institutions
- Tohoku University (JP)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1021/acs.joc.4c01793
- Citations
- 5
- Primary Topic
- Synthetic Organic Chemistry Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- Japan Society for the Promotion of Science