A CORRELAÇÃO ENTRE O USO DE ESCITALOPRAM EM IDOSOS E O PROLONGAMENTO DO INTERVALO QT.

To achieve the objective of verifying whether there is a correlation between the use of escitalopram in the elderly and QT prolongation, a search was carried out in Pubmed, Scielo and Lilacs. The selected studies were evaluated using the Newcastle-Ottawa scale to assesses study quality. The studies indicate that the link between escitalopram use and serious arrhythmia is weak despite FDA recommendations. The risk of arrhythmia and mortality associated with escitalopram also decreased over time. Cardiac comorbidities increase the risk of QT prolongation and mortality, and modifiable risk factors like hypokalemia and drug interactions should be addressed in at-risk individuals. Healthcare providers face a difficult decision regarding dosage restrictions and medication switching, taking into account escitalopram's effectiveness and tolerability. More research and awareness are needed to optimize antidepressant therapy for cardiac safety.

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Publication Details

Journal
Colloquium Vitae
Published
2024-09-10
DOI
https://doi.org/10.5747/cv.2024.v16.v373
Primary Topic
Functional Brain Connectivity Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

A CORRELAÇÃO ENTRE O USO DE ESCITALOPRAM EM IDOSOS E O PROLONGAMENTO DO INTERVALO QT.

Fernanda Cristina Poscai Ribeiro, Luiz Cláudio Behrmann Martins, Giuliana Forte, Bruna Kogici Mohammed Hateem
Colloquium Vitae
Functional Brain Connectivity Studies
article

A CORRELAÇÃO ENTRE O USO DE ESCITALOPRAM EM IDOSOS E O PROLONGAMENTO DO INTERVALO QT.

Fernanda Cristina Poscai Ribeiro, Luiz Cláudio Behrmann Martins, Giuliana Forte, Bruna Kogici Mohammed Hateem
article en

Abstract

To achieve the objective of verifying whether there is a correlation between the use of escitalopram in the elderly and QT prolongation, a search was carried out in Pubmed, Scielo and Lilacs. The selected studies were evaluated using the Newcastle-Ottawa scale to assesses study quality. The studies indicate that the link between escitalopram use and serious arrhythmia is weak despite FDA recommendations. The risk of arrhythmia and mortality associated with escitalopram also decreased over time. Cardiac comorbidities increase the risk of QT prolongation and mortality, and modifiable risk factors like hypokalemia and drug interactions should be addressed in at-risk individuals. Healthcare providers face a difficult decision regarding dosage restrictions and medication switching, taking into account escitalopram's effectiveness and tolerability. More research and awareness are needed to optimize antidepressant therapy for cardiac safety.

Colloquium VitaeVol. 16(1)
Universidade do Oeste Paulista (BR)
Openalex Percentile: Top 85%
Functional Brain Connectivity Studies
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