Determining the association of hyperoxia while on extracorporeal life support with mortality in neonates following Norwood operation
Neonates with hyperoxia (PaO<sub>2</sub> > 182 Torr) during the first 48-hour of ECLS post-Norwood operation had 5 times higher odds of mortality in the unadjusted analysis, however, this was insignificant when adjusting for confounding variables. Patients in the hyperoxia group had shorter duration from CICU arrival to ECLS-cannulation, higher serum lactate prior to ECLS-canulation, and higher ECLS flows in the first 4-hours, (p < 0.05). Multicenter evaluation of this modifiable risk factor is imperative to improve the care of this high-risk cohort.
Authors
- Subhadra Shashidharan
- Asaad G. Beshish (ORCID: https://orcid.org/0000-0003-2893-6882)
- David M. Kwiatkowski (ORCID: https://orcid.org/0000-0003-3331-9280)
- Alan Amedi
- Shayli Patel (ORCID: https://orcid.org/0009-0005-2703-0466)
- Amy Scheel (ORCID: https://orcid.org/0000-0001-6871-1552)
- Alaa Aljiffry (ORCID: https://orcid.org/0000-0003-1338-3242)
- Yijin Xiang (ORCID: https://orcid.org/0000-0001-8926-0236)
- Amanda Harding (ORCID: https://orcid.org/0009-0007-7621-328X)
- Sean Evans (ORCID: https://orcid.org/0000-0002-3903-2363)
- Ashley Harriott
- Joel Davis
Institutions
- Lucile Packard Children's Hospital (US)
- Emory University (US)
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- Journal of ExtraCorporeal Technology
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1051/ject/2024020
- Citations
- 1
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.11