Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of <i>Dalbergia gloveri</i>
Three new dihydroflavonols, gloverinols A-C (<b>1</b>-<b>3</b>), a new flavon-3-ol, gloverinol D (<b>4</b>), two new isoflavans, gloveriflavan A (<b>5</b>) and B (<b>6</b>), and seven known compounds were isolated from the root bark of <i>Dalbergia gloveri</i>. The structures of the isolates were elucidated by using NMR, ECD, and HRESIMS data analyses. Among the isolated compounds, gloverinol B (<b>2</b>), gloveriflavan B (<b>6</b>), and 1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphenyl)-1-propanone (<b>10</b>) were the most active against <i>Staphylococcus aureus</i>, with MIC values of 9.2, 18.4, and 14.2 μM, respectively.
Authors
- Duncan Mutiso Chalo (ORCID: https://orcid.org/0000-0002-8031-0927)
- Vaderament‐A. Nchiozem‐Ngnitedem (ORCID: https://orcid.org/0000-0001-8337-9260)
- Albert Ndakala (ORCID: https://orcid.org/0000-0003-0557-8410)
- Daniel Umereweneza (ORCID: https://orcid.org/0000-0001-8694-6400)
- Máté Erdélyi (ORCID: https://orcid.org/0000-0003-0359-5970)
- Ruisheng Xiong (ORCID: https://orcid.org/0000-0002-8165-5863)
- Ivan Kiganda
- Wouter Herrebout (ORCID: https://orcid.org/0000-0002-3167-8944)
- Abiy Yenesew (ORCID: https://orcid.org/0000-0002-1123-3200)
- Lianne H. E. Wieske (ORCID: https://orcid.org/0000-0003-4617-7605)
- Tomasz M. Karpiński (ORCID: https://orcid.org/0000-0001-6599-9204)
Institutions
- Poznan University of Medical Sciences (PL)
- Uppsala University (SE)
- University of Nairobi (KE)
- University of Antwerp (BE)
- University of Rwanda (RW)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1021/acs.jnatprod.4c00690
- Citations
- 8
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Vetenskapsrådet