Naldemedine for Opioid-Induced Constipation in Patients With Cancer: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial
Naldemedine prevented constipation and improved constipation-related QOL, with possible preventive effect on OINV in patients with cancer starting regularly dosed opioids therapy.
Authors
- Yoshiki Horie (ORCID: https://orcid.org/0000-0001-5568-6562)
- Tsumugi Jono (ORCID: https://orcid.org/0009-0006-7138-8702)
- Mami Hirakawa (ORCID: https://orcid.org/0000-0002-7067-2158)
- Ryuji Hayashi (ORCID: https://orcid.org/0000-0002-4205-9540)
- Michihiro Iwaki (ORCID: https://orcid.org/0000-0002-7650-0699)
- Kosuke Doki (ORCID: https://orcid.org/0000-0003-2497-0063)
- Yuko Kobayashi
- Tatsuya Morita (ORCID: https://orcid.org/0000-0002-7257-7429)
- Bryan J. Mathis (ORCID: https://orcid.org/0000-0002-9879-8289)
- Tomoki Ogata (ORCID: https://orcid.org/0009-0002-2953-2142)
- Jun Hamano (ORCID: https://orcid.org/0000-0003-0304-9881)
- Kosuke Tanaka (ORCID: https://orcid.org/0000-0002-5285-939X)
- Takahiro Higashibata (ORCID: https://orcid.org/0000-0002-1024-1946)
- Yoshiyuki Yamamoto (ORCID: https://orcid.org/0000-0002-2932-5904)
- Yuki Kasai (ORCID: https://orcid.org/0000-0003-3451-0124)
- Shinya Kajiura (ORCID: https://orcid.org/0000-0003-4920-5130)
- Yasuyuki Takashima
- Takaomi Kessoku (ORCID: https://orcid.org/0000-0002-5587-1386)
- Akiko Fuyuki (ORCID: https://orcid.org/0000-0003-1587-6980)
- Takayuki Ando (ORCID: https://orcid.org/0000-0001-8219-976X)
- Masato Homma (ORCID: https://orcid.org/0000-0002-4824-3242)
- Shunsuke Oyamada (ORCID: https://orcid.org/0000-0002-8130-6815)
- Takeshi Yamada (ORCID: https://orcid.org/0000-0001-7848-5827)
- Naoki Izawa
- Atsushi Nakajima
- Keisuke Ariyoshi
Institutions
- University of Tsukuba (JP)
- St. Marianna University School of Medicine (JP)
- Seirei Mikatabara General Hospital (JP)
- Japan Association for Development of Community Medicine (JP)
- University of Tsukuba Hospital (JP)
- Yokohama Sakae Kyosai Hospital (JP)
- Research Organization of Information and Systems (JP)
- University of Toyama (JP)
- International University of Health and Welfare (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1200/jco.24.00381
- Citations
- 13
- Primary Topic
- Pain Management and Opioid Use
- Type
- article
- Field-Weighted Citation Impact
- 8.34