Impact of Adjuvant Chemotherapy on Resected Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer: Results From an International Multicenter Study
Almost half of patients with resected IPMN-derived PDAC may be overtreated or undertreated. In patients with node-negative disease or normal CA19-9, adjuvant chemotherapy is not associated with a survival benefit, whereas those with node-positive disease and elevated CA19-9 have an associated benefit from adjuvant chemotherapy. A decision tree was proposed. Randomized controlled trials are needed for validation.
Authors
- Thilo Hackert (ORCID: https://orcid.org/0000-0002-7012-1196)
- Antonio Pea (ORCID: https://orcid.org/0000-0002-0509-6756)
- Marie Hecker
- Lily V. Saadat
- Matthew H. G. Katz (ORCID: https://orcid.org/0000-0003-3870-6968)
- Marc G. Besselink (ORCID: https://orcid.org/0000-0003-2650-9350)
- C. Max Schmidt (ORCID: https://orcid.org/0000-0003-2447-2128)
- Paul E. Oberstein (ORCID: https://orcid.org/0000-0001-5918-6004)
- Nader Hanna (ORCID: https://orcid.org/0000-0001-5755-5910)
- Isabella M. Frigerio (ORCID: https://orcid.org/0000-0002-7616-4226)
- Valentina Allegrini (ORCID: https://orcid.org/0000-0001-7323-0497)
- Kelly J. Lafaro (ORCID: https://orcid.org/0000-0002-7070-7269)
- Jörg Kaiser (ORCID: https://orcid.org/0000-0003-3980-4340)
- Giovanni Marchegiani (ORCID: https://orcid.org/0000-0002-6824-4533)
- Rachel C. Kim (ORCID: https://orcid.org/0000-0002-9670-7507)
- Markus W. Büchler (ORCID: https://orcid.org/0000-0002-3666-5675)
- Shailesh V. Shrikhande (ORCID: https://orcid.org/0000-0002-8036-4212)
- Peter J. Allen (ORCID: https://orcid.org/0000-0001-7912-9197)
- Benedict Kinny‐Köster (ORCID: https://orcid.org/0009-0003-7040-9725)
- Michael P. Kim (ORCID: https://orcid.org/0000-0002-8269-854X)
- Myrte Gorris (ORCID: https://orcid.org/0000-0001-6459-1434)
- Massimo Arcerito (ORCID: https://orcid.org/0000-0001-6906-9856)
- Christopher L. Wolfgang (ORCID: https://orcid.org/0009-0000-5817-6146)
- Joseph R. Habib (ORCID: https://orcid.org/0000-0003-3445-2278)
- Kevin C. Soares (ORCID: https://orcid.org/0000-0002-0406-017X)
- Chanjuan Shi (ORCID: https://orcid.org/0000-0001-5962-6479)
- Lois A. Daamen (ORCID: https://orcid.org/0000-0001-9227-7178)
- Floortje van Oosten
- Shuichi Watanabe (ORCID: https://orcid.org/0000-0002-0170-4937)
- Camilo Correa‐Gallego (ORCID: https://orcid.org/0000-0002-9776-0246)
- Jin Peng He (ORCID: https://orcid.org/0000-0001-9149-2247)
- Ammar A. Javed (ORCID: https://orcid.org/0000-0002-5463-5250)
- Jeremy Sharib (ORCID: https://orcid.org/0000-0002-1047-9823)
- Yi Miao (ORCID: https://orcid.org/0000-0003-2542-8663)
- Giovanni Butturini (ORCID: https://orcid.org/0000-0002-9172-4885)
- Min Tu (ORCID: https://orcid.org/0000-0003-1017-8825)
- Mahip Grewal
- Marco Del Chiaro (ORCID: https://orcid.org/0000-0001-9614-6466)
- Roberto Salvia
- Carlos Fernández-del Castillo
- I. Quintus Molenaar
- Laura R. Prakash
- Manish Bhandre
- Martin Loos
- Poitr Zelga
Institutions
- Champalimaud Foundation (PT)
- University of Verona (IT)
- University of Maryland, Baltimore (US)
- University of Maryland Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Padua (IT)
- Johns Hopkins University (US)
- Universität Hamburg (DE)
- Heidelberg University (DE)
- Johns Hopkins Medicine (US)
- Tata Memorial Hospital (IN)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
- Massachusetts General Hospital (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Amsterdam University Medical Centers (NL)
- Duke University Hospital (US)
- Indiana University School of Medicine
- University of Colorado Anschutz Medical Campus (US)
- Indiana University – Purdue University Indianapolis (US)
- New York University (US)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1200/jco.23.02313
- Citations
- 20
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 5.65