IDH2 regulates macrophage polarization and tumorigenesis by modulating mitochondrial metabolism in macrophages
Our findings suggest that IDH2 deficiency inhibits M2 macrophage polarization and suppresses tumorigenesis. This study underlines the potential contribution of IDH2 expression in macrophages and tumor microenvironment remodeling, which could be useful in clinical cancer research.
Authors
- So Yoon Kim (ORCID: https://orcid.org/0000-0001-7015-357X)
- Jung Bae Seong (ORCID: https://orcid.org/0000-0001-7423-0165)
- Hong Jun Lee
- Dong Kyu Choi (ORCID: https://orcid.org/0000-0002-6379-3074)
- Bokyung Kim (ORCID: https://orcid.org/0000-0001-9777-3437)
- Young‐Ho Park (ORCID: https://orcid.org/0000-0001-5405-1231)
- Dong‐Seok Lee (ORCID: https://orcid.org/0000-0002-7106-1615)
- Sung Woo Lee
- Eunbyul Yeom (ORCID: https://orcid.org/0009-0001-5926-1227)
Institutions
- Chungbuk National University (KR)
- Kyungpook National University (KR)
- Hanlim Pharm (South Korea) (KR)
- Bucheon University (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1186/s10020-024-00911-x
- Citations
- 11
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.65
Funders
- Ministry of Trade, Industry and Energy
- National Research Foundation of Korea