Novel approach to exploring protease activity and targets in HIV-associated obstructive lung disease using combined proteomic-peptidomic analysis
In HIV-associated OLD, a significant number of proteases are up-regulated, many of which are involved in protein degradation. These proteases degrade proteins involved in cell cycle and protein stability, thereby disrupting critical biological functions.
Authors
- Chris H. Wendt (ORCID: https://orcid.org/0000-0002-0924-8745)
- Timothy J. Griffin (ORCID: https://orcid.org/0000-0001-6801-2559)
- Sarah Samorodnitsky
- Monica Kruk (ORCID: https://orcid.org/0009-0005-6973-3207)
- Laurie L. Parker (ORCID: https://orcid.org/0000-0002-6234-3346)
- Eric F. Lock (ORCID: https://orcid.org/0000-0003-4663-2356)
- Pratik Dilip Jagtap (ORCID: https://orcid.org/0000-0003-0984-0973)
- Danielle O. Weise (ORCID: https://orcid.org/0000-0001-8644-8030)
- Subina Mehta (ORCID: https://orcid.org/0000-0001-9818-0537)
- Ken M. Kunisaki (ORCID: https://orcid.org/0000-0001-8644-2827)
- Alison Morris (ORCID: https://orcid.org/0000-0002-7290-6536)
- Janice M. Leung (ORCID: https://orcid.org/0000-0003-1682-6483)
Institutions
- University of Minnesota (US)
- University of British Columbia (CA)
- University of Pittsburgh (US)
- Minneapolis VA Health Care System (US)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1186/s12931-024-02933-9
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- University of Minnesota
- National Institutes of Health