Single-lung Transplant in a Patient with <i>Mycobacterium avium</i> Pulmonary Disease Successfully Treated with Amikacin Liposome Inhalation Suspension
A 55-year-old man presented to our hospital with idiopathic pulmonary fibrosis (IPF). He was registered with the Japan Organ Transplant Network the following year due to disease progression. Treatment with clarithromycin, ethambutol, and rifampicin for complications of Mycobacterium avium pulmonary disease was initiated, but sputum conversion could not be achieved. The administration of an amikacin liposome inhalation suspension (ALIS) resulted in sputum conversion, and single-lung transplantation was performed. ALIS therapy was continued after lung transplantation, and no M. avium disease was observed for 15 months. ALIS may cause M. avium pulmonary disease with additional indications for lung transplantation.
Authors
- Kadoaki Ohashi (ORCID: https://orcid.org/0000-0002-5180-3933)
- Kiichiro Ninomiya (ORCID: https://orcid.org/0000-0002-2134-2865)
- Shinichi Toyooka (ORCID: https://orcid.org/0000-0002-7588-6745)
- Go Makimoto (ORCID: https://orcid.org/0000-0002-0638-8435)
- Shunta Mori (ORCID: https://orcid.org/0000-0003-2511-8390)
- Eiki Ichihara (ORCID: https://orcid.org/0000-0002-2966-106X)
- Akihiko Taniguchi (ORCID: https://orcid.org/0000-0002-1170-1123)
- Kammei Rai (ORCID: https://orcid.org/0000-0001-5637-0762)
- Katsuyuki Hotta (ORCID: https://orcid.org/0000-0002-0112-0843)
- Shin Tanaka (ORCID: https://orcid.org/0000-0002-0014-9230)
- Hisao Higo (ORCID: https://orcid.org/0000-0003-4946-0123)
- Seiichiro Sugimoto (ORCID: https://orcid.org/0000-0001-6649-4777)
- Yoshinobu Maeda (ORCID: https://orcid.org/0009-0004-0051-0075)
- Masahiro Tabata
- Nobuaki Miyahara (ORCID: https://orcid.org/0000-0002-1972-6114)
- Masanori Fujii
- Kentaro Miyoshi
- Taichi Ozeki
- Hiroki Omori
Institutions
- Okayama University (JP)
- Okayama University Hospital (JP)
- Fukuyama Cardiovascular Hospital (JP)
- National Hospital Organization (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2024-09-10
- DOI
- https://doi.org/10.2169/internalmedicine.3854-24
- Citations
- 2
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.77