The Development of Radical/Palladium Relay Catalysis for C–H Carbonylation

Abstract The radical/palladium relay catalysis for C–H bond carbonylation is an attractive research topic in synthetic chemistry. It can rapidly prepare carbonylated molecules for synthetic or pharmaceutical applications from highly sought-after feedstocks, such as alkylarenes, alkanes, alkenes, or ethers. The main objective of this Synpacts article is to summarize the development of this research area, mainly focusing on radical/palladium relay catalysis for the carbonylation of single and double C–H bonds. 1 Introduction 2 Radical/Palladium Relay Catalysis for Single C–H Bond Carbonylation Reaction 3 Radical/Palladium Relay Catalysis for Double C–H Bond Carbonylation Reaction 4 Conclusions