Iridium-Catalyzed Leuckart-Type Reductive Amination of Carbonyls
Abstract Formamides are fundamental motifs that are prevalent in drugs, pesticides, dyes, and fragrances. Herein, we described an iridium-catalyzed Leuckart-type reductive amination of carbonyls, delivering formamides in moderate to excellent yields. In this process, ammonium formate was used as the N-formylating reagent to produce the formamide products. This protocol provides a new procedure for formamide synthesis.
Authors
- Renshi Luo (ORCID: https://orcid.org/0000-0001-8966-0387)
- Jinghui Tong
- Liang Liu (ORCID: https://orcid.org/0000-0002-8396-0554)
- Jianhua Liao
- Lu Ouyang (ORCID: https://orcid.org/0000-0002-5866-7823)
Institutions
- Shaoguan University (CN)
- Gannan Medical University (CN)
Publication Details
- Journal
- Synthesis
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1055/a-2412-9481
- Citations
- 1
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.16
Funders
- National Natural Science Foundation of China
- Shaoguan University
- Gannan Medical University