Cut-offs for relapse detection in men with stage I testicular germ cell tumors during active surveillance within a prospective multicentre cohort study using either raw or housekeeper normalized miR-371a-3p serum levels
Our preliminary data suggest that this CE-certified assay, using previously suggested cut-off values, is a promising method for detecting disease recurrence, provided a confirmatory second test is conducted to identify false positive results. To avoid unnecessary scans or overtreatment, we are currently validating this assay and cut-offs in a prospective cohort study.
Authors
- Silke Gillessen (ORCID: https://orcid.org/0000-0001-5746-6555)
- J. Beyer (ORCID: https://orcid.org/0000-0003-1755-9700)
- Ernest Kaufmann (ORCID: https://orcid.org/0009-0002-8250-4634)
- Christian D. Fankhauser (ORCID: https://orcid.org/0000-0002-4073-5488)
- Ailsa J. Christiansen (ORCID: https://orcid.org/0000-0002-8151-7444)
- Anja Lorch (ORCID: https://orcid.org/0000-0003-1681-3287)
- Christian Rothermundt (ORCID: https://orcid.org/0000-0002-2104-7794)
- Arnoud J. Templeton (ORCID: https://orcid.org/0000-0002-0847-7087)
- Richard Cathomas (ORCID: https://orcid.org/0000-0002-9677-9885)
- Thomas Hermanns
- Anita Hirschi-Blickenstorfer
- Silvan Sigg
- Marian S. Wettstein (ORCID: https://orcid.org/0000-0003-1378-3625)
Institutions
- University of Lucerne (CH)
- University of Basel (CH)
- University of Zurich (CH)
- Kantonsspital St. Gallen (CH)
- University Hospital of Bern (CH)
- Klinik Hirslanden (CH)
- University Hospital of Zurich (CH)
- Institute of Oncology Research (CH)
- Luzerner Kantonsspital (CH)
- Center for Pediatric Endocrinology Zurich (CH)
- St. Claraspital (CH)
- Kantonsspital Graubünden (CH)
- GastroZentrum Hirslanden Zürich (CH)
- Immunologie-Zentrum Zürich (CH)
- Università della Svizzera italiana (CH)
Publication Details
- Journal
- Urologic Oncology Seminars and Original Investigations
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1016/j.urolonc.2024.07.013
- Citations
- 1
- Primary Topic
- Testicular diseases and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.57