The impact of benign tissue within cancerous regions in the prostate: Characterizing sparse and dense prostate cancers on whole-mount histopathology and on multiparametric MRI
Histopathologically identified prostate cancer lesions were sparse in 37 % of cases. Sparse cancers were entirely low grade in TZ and predominantly low-grade in PZ and generally small, thus likely posing lower risk for spread and progression than dense lesions. Sparse lesions were not distinguishable from dense lesions on mpMRI, but could be distinguished from benign tissues.
Authors
- John V. Kurhanewicz (ORCID: https://orcid.org/0000-0002-3544-5339)
- Jeffry Simko
- Peter R. Carroll (ORCID: https://orcid.org/0000-0002-1086-4334)
- Olga Starobinets
- Matthew Gibbons (ORCID: https://orcid.org/0000-0003-4108-6157)
- Susan M. Noworolski (ORCID: https://orcid.org/0000-0003-1609-2790)
Institutions
- University of California, San Francisco (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Magnetic Resonance Imaging
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1016/j.mri.2024.110233
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Cancer Institute