EFFECT OF SUBANAESTHETIC DOSE OF KETAMINE IN CARDIAC SURGERY

Background: to evaluate the effectiveness of general anesthesia (GA) in combination with a subanesthetic dose of ketamine during cardiac surgery under cardiopulmonary bypass (CPB). Material and methods. Cardiac surgery patients were divided into two groups: group 1 (n=21) – GMEA based on sevoflurane (before and after CPB), propofol (during CPB), fentanyl and pipecuronium; Group 2 (n=18) – GA in combination with ketamine administration (bolus – 25 mg, then titrated – 25 mg/h). The comparison of the parameters of anesthesia, endocrine-metabolic monitoring, perioperative hemodynamic parameters, and pain level was made. Results. In the patient groups at the study stages no statistically significant differences in the values of cortisol, prolactin, glucose and blood lactate were found. The duration of mechanical ventilation, pain, doses of morphine and paracetamol did not differ in the postoperative period. Conclusions. The studied methods of anesthesia during cardiac surgery with CPB did not have differences in the parameters of endocrine-metabolic monitoring. The use of GA in combination with ketamine is characterized by less fluctuation in blood pressure during the study phases: 5 minutes after sternotomy, 15 minutes before the start of CPB and the patient's admission to the intensive care unit.