IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca <sup>2+</sup> Homeostasis
Cardiac IRS2 inhibits sympathetic stress-induced AKT/NOS3/CaMKII/RyR2 overactivation and calcium-dependent arrhythmogenesis. This novel IRS2 signaling axis, essential for maintaining cardiac calcium homeostasis under stress, presents a promising target for developing new antiarrhythmic therapies.
Authors
- Hamza Malik (ORCID: https://orcid.org/0009-0008-2758-9835)
- Qian Shi (ORCID: https://orcid.org/0000-0003-2634-9553)
- Yuval Itan (ORCID: https://orcid.org/0000-0003-4966-3238)
- E. Dale Abel (ORCID: https://orcid.org/0000-0001-5290-0738)
- Xuguang Li (ORCID: https://orcid.org/0000-0002-0187-6616)
- Long‐Sheng Song (ORCID: https://orcid.org/0000-0002-6035-8106)
- Biyi Chen (ORCID: https://orcid.org/0000-0003-0402-7537)
- Jennifer Streeter (ORCID: https://orcid.org/0000-0002-6965-9546)
- Duane D. Hall (ORCID: https://orcid.org/0000-0003-2228-0966)
- Jinxi Wang (ORCID: https://orcid.org/0000-0002-7349-6153)
- David Stein (ORCID: https://orcid.org/0000-0002-5131-8313)
- Eric T. Weatherford (ORCID: https://orcid.org/0000-0002-4890-2359)
- Jacob Sharafuddin (ORCID: https://orcid.org/0009-0003-1024-7568)
Institutions
- University of Iowa (US)
- United States Department of Energy (US)
- University of California, Los Angeles (US)
- Fraternal Order of Eagles (US)
- Child Health and Development Institute (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Circulation
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1161/circulationaha.123.065048
- Citations
- 3
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.21