Predicting treatment resistance in positive and negative symptom domains from first episode psychosis: Development of a clinical prediction model
Treatment resistance of positive symptoms can be accurately predicted from FEP using routinely collected baseline data, however prediction of negative domain-TR remains a challenge. Detailed negative symptom domains, clinical data, and biomarkers should be considered in future longitudinal studies.
Authors
- Stephen James Wood (ORCID: https://orcid.org/0000-0003-4186-5919)
- Nick Freemantle (ORCID: https://orcid.org/0000-0001-5807-5740)
- Paris Alexandros Lalousis (ORCID: https://orcid.org/0000-0001-9642-3080)
- Laura Bravo-Merodio (ORCID: https://orcid.org/0000-0001-8878-8434)
- Rachel Upthegrove (ORCID: https://orcid.org/0000-0001-8204-5103)
- David Fowler (ORCID: https://orcid.org/0000-0001-5806-2659)
- Linda Everard
- Peter Brian Jones (ORCID: https://orcid.org/0000-0002-0387-880X)
- Swaran P. Singh (ORCID: https://orcid.org/0000-0003-3454-2089)
- Max Birchwood (ORCID: https://orcid.org/0000-0002-7476-0171)
- Siân Lowri Griffiths (ORCID: https://orcid.org/0000-0003-0031-7174)
- Georgios V. Gkoutos (ORCID: https://orcid.org/0000-0002-2061-091X)
- Rebecca Lee (ORCID: https://orcid.org/0000-0003-2540-2009)
- Joanne Hodegkins
- Tim Amos
Institutions
- University of East Anglia (GB)
- University of Sussex (GB)
- King's College London (GB)
- University of Cambridge (GB)
- Birmingham and Solihull Mental Health NHS Foundation Trust (GB)
- University of Bristol (GB)
- University of Warwick (GB)
- Mental Health Foundation (GB)
- MRC Clinical Trials Unit at UCL (GB)
- University College London (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Schizophrenia Research
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1016/j.schres.2024.09.010
- Citations
- 4
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.54
Funders
- National Institute for Health and Care Research
- King's College London
- University of Birmingham