INDICATORS OF LOCAL ORAL IMMUNITY IN USERS OF NEW TYPES OF TOBACCO PRODUCTS

Introduction. The organs and structures of the oral cavity are among the first to come into contact with the aerosol when using electronic cigarettes and heated-tobacco products, and some of the aerosol components enter various biological fluids of the mouth, inevitably provoking a response of the body to external influences. One of the markers of the response are immunoglobulins, and their analysis is intended to help in studying the effect of electronic cigarettes and heated-tobacco products on humans. Objective. The aim of the study was to estimate changes in immunoglobulins A, G and M of gingival fluid, oral fluid and saliva among users of new types of tobacco products. Material and methods. The study included 4 groups of 5 people each: regular cigarette smokers, e-cigarette users, users of tobacco heating sys-tems and non-smokers. For laboratory studies, gingival fluid, saliva and oral fluid were taken from the subjects. Results. Various changes in the concentration of immunoglobulins relative to the control group were observed in all groups of smoking patients. Conclusion. The results may indicate inhibition of the function of local immunity both when exposed to tobacco smoke and when exposed to aerosol of heated-tobacco products or electronic cigarettes, which increases the vulnerability of organs and structures of the oral cavity to pathogenic microor-ganisms.