CAR expression in invasive breast carcinoma and its effect on adenovirus transduction efficiency
The present study demonstrates that oncolytic adenoviral therapy is less effective in ILC than IDC due to differences in spatial CAR expression. Liposome-enhanced delivery may be beneficial for patients with ILC and tumors with low or negative CAR expression to improve adenoviral therapeutic effectiveness.
Authors
- Omonigho Aisagbonhi (ORCID: https://orcid.org/0000-0001-7855-8619)
- Abraham T. Phung (ORCID: https://orcid.org/0000-0001-8146-0794)
- Christopher Larson (ORCID: https://orcid.org/0000-0002-4224-0649)
- Bryan Oronsky (ORCID: https://orcid.org/0000-0002-3940-6329)
- Andrew C. Kummel (ORCID: https://orcid.org/0000-0001-8301-9855)
- William C. Trogler (ORCID: https://orcid.org/0000-0001-6098-7685)
- Sarah L. Blair (ORCID: https://orcid.org/0000-0003-0477-4049)
- Jaimin R. Shah (ORCID: https://orcid.org/0000-0002-8894-8853)
- Ana B. Sanchez (ORCID: https://orcid.org/0000-0003-4661-8378)
- Tao Dong (ORCID: https://orcid.org/0000-0002-9506-9136)
- Tony Reid
Institutions
- UC San Diego Health System (US)
- University of California San Diego (US)
- Epicentre (South Africa) (ZA)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1186/s13058-024-01880-z
- Citations
- 5
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- EpicentRx
- University of California, San Diego
- National Cancer Institute
- Division of Chemistry