Inhibition of STAT3 by 2-Methoxyestradiol suppresses M2 polarization and protumoral functions of macrophages in breast cancer
Our study presents novel findings on mechanism of 2ME2 from the perspective of its effects on the polarization of the TAMs via the STAT3 signaling in breast cancer. Altogether, the data supports further clinical investigation of 2ME2 and its derivatives as therapeutic agents to modulate the tumor microenvironment and immune response in breast carcinoma.
Authors
- Manoj Garg (ORCID: https://orcid.org/0000-0002-3492-2957)
- Sonia Kapoor (ORCID: https://orcid.org/0000-0003-2226-8748)
- Manas Kumar Santra (ORCID: https://orcid.org/0000-0002-8899-4518)
- Bhawna Deswal (ORCID: https://orcid.org/0000-0002-6086-229X)
- Urmi Bagchi
Institutions
- Amity University (IN)
- National Centre for Cell Science (IN)
- Amity University (AE)
- Savitribai Phule Pune University (IN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1186/s12885-024-12871-w
- Citations
- 17
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.09
Funders
- Aimmune Therapeutics
- Department of Science and Technology, Ministry of Science and Technology, India
- Amity University
- Science and Engineering Research Board