World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guideline update – XI – Milk supplement/replacement formulas for infants and toddlers with CMA – Systematic review
Currently available studies comparing eHF-CM, AAF, HRF, and SF provide very low certainty evidence about their effects in infants with IgE-mediated and non-IgE-mediated CMA. Our review revealed several limitations in the current body of evidence, primarily arising from concerns related to the quality of studies, the limited size of the participant populations and most importantly the lack of diversity and standardization in the compared interventions. It is therefore imperative for future studies to be methodologically rigorous and investigate a broader spectrum of available interventions. We encourage clinicians and researchers to review current World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines for suggestions on how to use milk replacement formulas in clinical practice and what additional research would be the most beneficial.
Authors
- Gideon Lack (ORCID: https://orcid.org/0000-0001-7350-4021)
- Arnav Agarwal (ORCID: https://orcid.org/0000-0001-5780-725X)
- Lamia Dahdah (ORCID: https://orcid.org/0000-0002-4079-5317)
- Jan Brożek (ORCID: https://orcid.org/0000-0002-3122-0773)
- Siw Waffenschmidt (ORCID: https://orcid.org/0000-0001-6860-6699)
- Rose Kamenwa (ORCID: https://orcid.org/0000-0003-2708-6978)
- Carina Venter (ORCID: https://orcid.org/0000-0002-7473-5355)
- Elena Galli
- Ruby Pawankar (ORCID: https://orcid.org/0000-0002-3091-7237)
- Luigi Terracciano (ORCID: https://orcid.org/0000-0002-9393-9660)
- Ignacio Javier Ansotegui (ORCID: https://orcid.org/0000-0002-6942-1511)
- Yvan Vandenplas (ORCID: https://orcid.org/0000-0002-1862-8651)
- Hania Szajewska (ORCID: https://orcid.org/0000-0002-4596-2874)
- Alberto M. Martelli (ORCID: https://orcid.org/0000-0001-5196-7260)
- Piotr Dziechciarz (ORCID: https://orcid.org/0000-0003-4227-3130)
- Amal Assa’ad (ORCID: https://orcid.org/0000-0001-7791-6859)
- Jonathan M. Spergel (ORCID: https://orcid.org/0000-0002-4658-5353)
- Yetiani Roldán (ORCID: https://orcid.org/0009-0009-4564-5973)
- Susan Waserman (ORCID: https://orcid.org/0000-0002-2136-5995)
- Antonio Bognanni (ORCID: https://orcid.org/0000-0003-0128-903X)
- Raanan Shamir (ORCID: https://orcid.org/0000-0002-4287-3681)
- Anna Nowak‐Węgrzyn (ORCID: https://orcid.org/0000-0002-0960-9854)
- Andrea Horvath (ORCID: https://orcid.org/0000-0001-9940-0001)
- Motohiro Ebisawa (ORCID: https://orcid.org/0000-0003-4117-558X)
- Alessandro Fiocchi (ORCID: https://orcid.org/0000-0002-2549-0523)
- Ramon Targino Firmino (ORCID: https://orcid.org/0000-0001-5581-0658)
- Hanako Mihara
- Stefania Arasi (ORCID: https://orcid.org/0000-0002-8135-0568)
- Holger J. Schünemann (ORCID: https://orcid.org/0000-0003-3211-8479)
- Gary Wong (ORCID: https://orcid.org/0000-0001-5939-812X)
- Christophe Dupont (ORCID: https://orcid.org/0000-0002-4943-6329)
- Derek K. Chu (ORCID: https://orcid.org/0000-0001-8269-4496)
- Martín Bózzola (ORCID: https://orcid.org/0000-0003-3718-7086)
- Maria Said
- Sami L. Bahna (ORCID: https://orcid.org/0000-0003-2113-1870)
- Nikolaos G. Papadopoulos (ORCID: https://orcid.org/0000-0002-4448-3468)
- A. Chu (ORCID: https://orcid.org/0000-0003-0201-2630)
- Anna Starok
- Haiqi Li
- Amena Warner (ORCID: https://orcid.org/0000-0001-8995-9055)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Children's Hospital of Philadelphia (US)
- Humanitas University (IT)
- Vrije Universiteit Brussel (BE)
- Chinese University of Hong Kong (HK)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- National and Kapodistrian University of Athens (GR)
- Medical University of Warsaw (PL)
- Aga Khan University Hospital Nairobi (KE)
- Institute for Quality and Efficiency in Health Care (DE)
- Universidade Federal de Campina Grande (BR)
- Children's Hospital Colorado (US)
- Space Research Institute (UA)
- ENT and Allergy (US)
- Aga Khan University Nairobi (KE)
- Fatebenefratelli Hospital (IT)
- Italian Society of Physiotherapy (IT)
- Schneider Children's Medical Center (IL)
- Hospital Quirónsalud Barcelona (ES)
- National Sagamihara Hospital (JP)
- Modern Water (United Kingdom) (GB)
- Bambino Gesù Children's Hospital (IT)
- Institut Marcel Mauss (FR)
- Belgian Health Care Knowledge Centre (KCE) (BE)
- Lukasiewicz Research Network - Krakow Institute of Technology (PL)
- Hospital Británico de Buenos Aires (AR)
- Nippon Medical School Hospital (JP)
- Children's Hospital of Chongqing Medical University (CN)
- Impact (CA)
- University of Warmia and Mazury in Olsztyn (PL)
- New York University (US)
- University of Pennsylvania (US)
- Nippon Medical School (JP)
- Louisiana State University Health Sciences Center Shreveport (US)
- Chongqing Medical University (CN)
- University of Colorado Denver (US)
- McMaster University (CA)
Publication Details
- Journal
- World Allergy Organization Journal
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.waojou.2024.100947
- Citations
- 8
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 3.06
Funders
- Amgen
- Pfizer
- AstraZeneca
- Sanofi
- Mead Johnson Nutrition
- Danone
- CSL Behring
- Regeneron Pharmaceuticals
- BioCryst
- Aimmune Therapeutics
- Mylan
- Action Medical Research
- Bausch Health
- Food Allergy Canada
- National Institutes of Health
- Medical Research Council