Fenofibrate attenuates renal lipotoxicity in uninephrectomized mice with high-fat diet-induced obesity
Peroxisome proliferator-activated receptor-α activation by fenofibrate, with subsequent lipolysis, attenuated glomerular and tubulointerstitial lesions induced by renal lipotoxicity, thus protecting the kidneys of uninephrectomy mice from obesity-induced lesions. The study findings suggest a pathway in the pharmacological action of fenofibrate, providing insight into the mechanisms involved in kidney damage caused by obesity in kidney donors.
Authors
- Helady Sanders‐Pinheiro (ORCID: https://orcid.org/0000-0001-8603-1331)
- Bianca de Fátima Pereira (ORCID: https://orcid.org/0000-0002-2600-0901)
- Bárbara Bruna Abreu de Castro (ORCID: https://orcid.org/0000-0002-5224-677X)
- Petrus Ferreira Renó (ORCID: https://orcid.org/0000-0002-7927-341X)
- Niels Olsen Saraiva Câmara (ORCID: https://orcid.org/0000-0001-5436-1248)
- Marcos Antônio Cenedeze (ORCID: https://orcid.org/0000-0002-8878-6268)
- Fabiana Oliveira Bastos Bonato (ORCID: https://orcid.org/0000-0003-1566-4224)
- Kaique Arriel (ORCID: https://orcid.org/0000-0002-3984-2964)
- Fernando Antônio Basile Colugnati (ORCID: https://orcid.org/0000-0002-8288-203X)
Institutions
- Universidade Federal de Juiz de Fora (BR)
- Universidade de São Paulo (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Brazilian Journal of Nephrology
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1590/2175-8239-jbn-2023-0148en
- Citations
- 2
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais