A serum B-lymphocyte activation signature is a key distinguishing feature of the immune response in sarcoidosis compared to tuberculosis
Sarcoidosis and tuberculosis (TB) are two granulomatous diseases that often share overlapping clinical features, including uveitis. We measured 368 inflammation-related proteins in serum in both diseases, with and without uveitis from two distinct geographically separated cohorts: sarcoidosis from the Netherlands and TB from Indonesia. A total of 192 and 102 differentially expressed proteins were found in sarcoidosis and active pulmonary TB compared to their geographical healthy controls, respectively. While substantial overlap exists in the immune-related pathways involved in both diseases, activation of B cell activating factor (BAFF) signaling and proliferation-inducing ligand (APRIL) mediated signaling pathways was specifically associated with sarcoidosis. We identified a B-lymphocyte activation signature consisting of BAFF, TNFRSF13B/TACI, TRAF2, IKBKG, MAPK9, NFATC1, and DAPP1 that was associated with sarcoidosis, regardless of the presence of uveitis. In summary, a difference in B-lymphocyte activation is a key discriminative immunological feature between sarcoidosis/ocular sarcoidosis (OS) and TB/ocular TB (OTB).
Authors
- Nicole M. A. Nagtzaam
- Benjamin Schrijver
- P. Martin van Hagen (ORCID: https://orcid.org/0000-0003-0854-2368)
- Rina La Distia Nora (ORCID: https://orcid.org/0000-0002-7026-5341)
- Jan van Laar (ORCID: https://orcid.org/0000-0002-8885-4929)
- Saskia M. Rombach (ORCID: https://orcid.org/0000-0003-1356-7033)
- Josianne C. ten Berge (ORCID: https://orcid.org/0000-0003-4610-4991)
- P. Martijn Kolijn (ORCID: https://orcid.org/0000-0002-2139-637X)
- Willem A. Dik (ORCID: https://orcid.org/0000-0001-5235-3156)
- Hanna IJspeert (ORCID: https://orcid.org/0000-0002-7061-5321)
- Astrid C. van Stigt (ORCID: https://orcid.org/0000-0003-0698-4672)
- Ikhwanuliman Putera (ORCID: https://orcid.org/0000-0002-9350-5133)
- Sigrid Swagemakers (ORCID: https://orcid.org/0000-0003-4339-8189)
- Rupesh Agrawal
Institutions
- Nanyang Technological University (SG)
- Erasmus MC (NL)
- Tan Tock Seng Hospital (SG)
- University of Indonesia (ID)
- SingHealth Duke-NUS Academic Medical Centre (SG)
- Singapore Eye Research Institute (SG)
- Duke-NUS Medical School (SG)
- Moorfields Eye Hospital (GB)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- University College London (GB)
Publication Details
- Journal
- Communications Biology
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1038/s42003-024-06822-1
- Citations
- 9
- Primary Topic
- Sarcoidosis and Beryllium Toxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Lembaga Pengelola Dana Pendidikan