Unveiling the impact of SUMOylation at K298 site of heat shock factor 1 on glioblastoma malignant progression
This study elucidates the significance of SUMOylation modification of HSF1 in driving GBM progression. Targeting SUMOylated HSF1 may offer a novel therapeutic approach for GBM treatment. Further investigation into the specific molecular mechanisms influenced by SUMOylated HSF1 is warranted for the development of effective targeted therapies to improve outcomes for GBM patients.
Authors
- Kun Dai (ORCID: https://orcid.org/0000-0002-7487-7556)
- Zongqi Wang (ORCID: https://orcid.org/0000-0003-4559-3420)
- Zhengquan Yu
- Bixi Gao (ORCID: https://orcid.org/0000-0002-2978-0691)
- Xiang Li (ORCID: https://orcid.org/0000-0003-2643-8812)
- Jiang Wu (ORCID: https://orcid.org/0000-0002-1063-3878)
- Long‐Yuan Li (ORCID: https://orcid.org/0000-0001-7472-8318)
- Haitao Shen (ORCID: https://orcid.org/0000-0003-3111-0133)
- Kecheng Shen (ORCID: https://orcid.org/0000-0001-7461-4521)
- Guangzhao Li (ORCID: https://orcid.org/0000-0002-5007-8338)
- Haiying Li
- Zhong Wang
- Xin Wu
- Gang Chen (ORCID: https://orcid.org/0000-0003-1683-7676)
- Xiaowang Niu
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Neoplasia
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1016/j.neo.2024.101055
- Citations
- 8
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China