Investigating the Impact of Hibiscus Extracts on Paraoxonase and Antioxidant Activities in Diabetic Rats

Objective: Diabetes mellitus (DM) accelerates oxidative stress beyond its broad effects on metabolic function, which has been linked to various chronic complications. This study investigated the antioxidative and therapeutic potential of Hibiscus syriacus (HSE) and Hibiscus trionum extracts (HTE), focusing on their effects on paraoxonase (PON) and arylesterase enzymes activity in diabetic rat models. Material and Methods: This study evaluated PON and ARE activities in 36 Wistar albino rats divided into the following groups: control (C), C+HSE, C+HTE, Diabetes (D), D+HSE, and D+HTE. The total phenolic content of HSE and HTE was determined using the Folin- Ciocalteu method, and their antioxidant activities were assessed using DPPH and CUPRAC tests. Results: HSE and HTE extracts have demonstrated significant increases in paraoxonase and arylesterase activities, which are crucial for cardiovascular protection and reducing oxidative stress in diabetes. Conclusions: This study highlights the potential of natural extracts in managing oxidative stress-related complications associated with diabetes and underscores the need to integrate such phytotherapeutic agents into broader diabetes care strategies. Future research should focus on confirming these findings in clinical settings and investigating the molecular processes responsible for the observed effects, potentially paving the way for innovative interventions for diabetes management.