GMP-compliant automated radiosynthesis of [18F] SynVesT-1 for PET imaging of synaptic vesicle glycoprotein 2 A (SV2A)
The use of AIO synthesizer maintains high production yields and increases reliability, reduces production time and allows rapid training of production staff. Besides, the as-prepared [<sup>18</sup>F] SynVesT-1 displays excellent in vivo binding properties in humans and holds great potential for the imaging and quantification of synaptic density in vivo.
Authors
- Yaping Wu (ORCID: https://orcid.org/0000-0002-2979-5332)
- Xiaochen Li (ORCID: https://orcid.org/0000-0002-3215-1095)
- Xiaoqi Wang (ORCID: https://orcid.org/0000-0002-2700-1017)
- Weifeng Zhang (ORCID: https://orcid.org/0000-0003-3409-5661)
- Xiaona Li (ORCID: https://orcid.org/0000-0002-1240-4366)
- Meiyun Wang (ORCID: https://orcid.org/0000-0002-7163-2617)
- Jianfei Liang
- Yao Ge (ORCID: https://orcid.org/0009-0001-7802-4091)
- Huiqiang Li (ORCID: https://orcid.org/0000-0003-1375-9908)
- Lijuan Chen (ORCID: https://orcid.org/0000-0002-6761-1338)
- Xiaosheng Song (ORCID: https://orcid.org/0000-0002-1009-3226)
- Yunjuan Wang
- Yan Bai (ORCID: https://orcid.org/0000-0001-8779-6184)
- Ruili Li
Institutions
- Beijing Institute of Petrochemical Technology (CN)
- Henan University (CN)
- Zhengzhou University (CN)
- Henan Academy of Sciences (CN)
- Beijing Founder Electronics (China) (CN)
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1186/s41181-024-00284-w
- Citations
- 3
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- National Natural Science Foundation of China
- Fudan University
- Huashan Hospital