The SIX2/PFN2 feedback loop promotes the stemness of gastric cancer cells
This study unveils the roles of SIX2 in governing GC cell stemness, defining a novel SIX2/PFN2 regulatory loop responsible for this regulation. This suggests the potential of targeting the SIX2/PFN2 loop for GC treatment (Graphical Abstracts).
Authors
- Shengtao Xu (ORCID: https://orcid.org/0000-0002-5705-6377)
- Miaomiao Niu (ORCID: https://orcid.org/0000-0001-6368-8525)
- Haiwei Ni
- Yi Zhou (ORCID: https://orcid.org/0009-0009-7613-8026)
- Lufeng Zheng (ORCID: https://orcid.org/0000-0002-2183-4974)
- Qianqian Guo (ORCID: https://orcid.org/0000-0001-6314-3082)
- Wenzhou Zhang (ORCID: https://orcid.org/0000-0001-7112-392X)
Institutions
- Jiangsu University (CN)
- China Pharmaceutical University (CN)
- First People's Hospital of Kunshan (CN)
- Henan Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-10
- DOI
- https://doi.org/10.1186/s12967-024-05618-5
- Citations
- 7
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Henan Provincial Science and Technology Research Project