Stand-alone segmentation of blood flow pulsatility measured with diffuse correlation spectroscopy
We present a stand-alone blood flow index (BFI) pulse segmentation method for diffuse correlation spectroscopy that uses a wavelet-based representation of the BFI signal at the cardiac frequency in place of an exogenous physiological reference. We use this wavelet-based segmentation method to quantify BFI waveform morphology in a cohort of 30 healthy adults. We demonstrate that the waveform morphology features obtained with the wavelet approach strongly agree with those obtained using an exogenous blood pressure reference signal. These results suggest the promise of stand-alone wavelet-based BFI segmentation for quantifying BFI waveform morphological features.
Authors
- Srinidhi Bharadwaj (ORCID: https://orcid.org/0000-0002-1200-0070)
- Hongting Zhao (ORCID: https://orcid.org/0000-0001-5356-8220)
- Katherine Turrentine
- Rowan O. Brothers (ORCID: https://orcid.org/0000-0003-0587-4578)
- Sydney E. Triplett (ORCID: https://orcid.org/0009-0000-8553-5909)
- Tara M. Urner (ORCID: https://orcid.org/0000-0001-7030-9255)
- Shasha Bai (ORCID: https://orcid.org/0000-0003-4999-327X)
- Vidisha Goyal (ORCID: https://orcid.org/0000-0001-8065-5522)
- Yueh‐Chi Wu
- Ayesha Quadri
- Mariam Akbar
- Tisha Boodooram
- Eashani Sathialingam (ORCID: https://orcid.org/0000-0001-6190-049X)
- Kyle R. Cowdrick (ORCID: https://orcid.org/0000-0003-2236-6137)
- Erin M. Buckley (ORCID: https://orcid.org/0000-0003-1068-8411)
Institutions
- Georgia Institute of Technology (US)
- Emory Healthcare (US)
- Emory University (US)
- Emory and Henry College (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- Biomedical Optics Express
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1364/boe.533916
- Citations
- 1
- Primary Topic
- Optical Imaging and Spectroscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- National Science Foundation
- Emory University
- Georgia Clinical and Translational Science Alliance
- National Heart, Lung, and Blood Institute
- National Institute of Neurological Disorders and Stroke
- National Center for Advancing Translational Sciences