<scp>SOX17</scp> expression in mesonephric‐like adenocarcinomas and mesonephric remnants/hyperplasia of the female genital tract: Expanding its utility as a Müllerian biomarker
The majority of MLA are negative or exhibit low SOX17 expression, in contrast to the diffuse and strong expression commonly seen in other types of Müllerian carcinoma. However, a subset of MLAs demonstrate high SOX17 expression. Therefore, absence of SOX17 staining is supportive for MLA when the differential includes another non-mucinous Müllerian carcinoma. SOX17 may also be useful for differentiating mesonephric remnants/hyperplasias from Müllerian malignancies and benign Müllerian glandular lesions.
Authors
- W. Glenn McCluggage (ORCID: https://orcid.org/0000-0001-9178-4370)
- Michelle S. Hirsch (ORCID: https://orcid.org/0000-0002-8767-8564)
- Brooke E. Howitt (ORCID: https://orcid.org/0000-0002-0309-6680)
- Xiaoming Zhang (ORCID: https://orcid.org/0000-0001-9764-8986)
Institutions
- Brigham and Women's Hospital (US)
- Belfast Health and Social Care Trust (GB)
- Harvard University (US)
- Stanford University (US)
Publication Details
- Journal
- Histopathology
- Published
- 2024-09-08
- DOI
- https://doi.org/10.1111/his.15308
- Citations
- 6
- Primary Topic
- Uterine Myomas and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.50