<scp>SOX17</scp> expression in mesonephric‐like adenocarcinomas and mesonephric remnants/hyperplasia of the female genital tract: Expanding its utility as a Müllerian biomarker

The majority of MLA are negative or exhibit low SOX17 expression, in contrast to the diffuse and strong expression commonly seen in other types of Müllerian carcinoma. However, a subset of MLAs demonstrate high SOX17 expression. Therefore, absence of SOX17 staining is supportive for MLA when the differential includes another non-mucinous Müllerian carcinoma. SOX17 may also be useful for differentiating mesonephric remnants/hyperplasias from Müllerian malignancies and benign Müllerian glandular lesions.

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Publication Details

Journal
Histopathology
Published
2024-09-08
DOI
https://doi.org/10.1111/his.15308
Citations
6
Primary Topic
Uterine Myomas and Treatments
Type
article
Field-Weighted Citation Impact
3.50
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article

SOX17 expression in mesonephric‐like adenocarcinomas and mesonephric remnants/hyperplasia of the female genital tract: Expanding its utility as a Müllerian biomarker

W. Glenn McCluggage, Michelle S. Hirsch, Brooke E. Howitt, Xiaoming Zhang
6 citations
Histopathology
Uterine Myomas and Treatments
3.50
article

SOX17 expression in mesonephric‐like adenocarcinomas and mesonephric remnants/hyperplasia of the female genital tract: Expanding its utility as a Müllerian biomarker

W. Glenn McCluggage, Michelle S. Hirsch, Brooke E. Howitt, Xiaoming Zhang
article en
6 citations

Abstract

The majority of MLA are negative or exhibit low SOX17 expression, in contrast to the diffuse and strong expression commonly seen in other types of Müllerian carcinoma. However, a subset of MLAs demonstrate high SOX17 expression. Therefore, absence of SOX17 staining is supportive for MLA when the differential includes another non-mucinous Müllerian carcinoma. SOX17 may also be useful for differentiating mesonephric remnants/hyperplasias from Müllerian malignancies and benign Müllerian glandular lesions.

HistopathologyVol. 85(5)
Brigham and Women's Hospital (US), Belfast Health and Social Care Trust (GB), Harvard University (US), Stanford University (US)
Good health and well-being
Openalex Percentile: Top 7%
Uterine Myomas and Treatments
3.50
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