Neuroprotection of isoorientin against microglia activation induced by lipopolysaccharide via regulating GSK3β, NF-κb and Nrf2/HO-1 pathways
<b>Conclusion:</b> ISO attenuated the activation of microglia through regulating the GSK3β, NF-κB and Nrf2/HO-1 signaling pathways to exert neuroprotection.
Authors
- Yan Dong (ORCID: https://orcid.org/0000-0003-0915-6223)
- Qing X. Li (ORCID: https://orcid.org/0000-0003-4589-2869)
- Xiaoqin Tan (ORCID: https://orcid.org/0000-0001-7929-1178)
- Yingui Li (ORCID: https://orcid.org/0000-0002-8559-9619)
- Yijing Zhao (ORCID: https://orcid.org/0000-0001-8243-8505)
- Lang Yi (ORCID: https://orcid.org/0000-0002-9321-9022)
- Mindie Cao
- Changhong He
Institutions
- Guangzhou University of Chinese Medicine (CN)
- University of Hawaiʻi at Mānoa (US)
- Wuhan College (CN)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2024-09-08
- DOI
- https://doi.org/10.1080/08923973.2024.2399249
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.99
Funders
- Hawaii Community Foundation
- National Natural Science Foundation of China