Glucocorticoid receptor response and glucocorticoid-induced leucine zipper expression in neutrophils of critically ill patients with traumatic and non-traumatic brain injury
We provide novel evidence on the downregulated expression and upregulated signaling of the ligand-binding and functionally active GCR-α isoform in the polymorphonuclear neutrophils (PMNs) of critically ill patients with BI. The increased <i>GILZ</i> expression indicates an increased GC sensitivity in the PMNs of BI critically ill patients.
Authors
- Maria Pratikaki
- Nikolaos S. Lotsios (ORCID: https://orcid.org/0000-0002-7194-3976)
- Charikleia S. Vrettou (ORCID: https://orcid.org/0000-0002-1067-8849)
- Ioanna Dimopoulou (ORCID: https://orcid.org/0000-0002-2219-7292)
- Chrysi Keskinidou (ORCID: https://orcid.org/0000-0002-4047-3588)
- Dimitra A. Vassiliadi (ORCID: https://orcid.org/0000-0002-3403-8977)
- Αnastasia Kotanidou (ORCID: https://orcid.org/0000-0002-2508-500X)
- Alice G. Vassiliou (ORCID: https://orcid.org/0000-0003-4984-0476)
- Vassiliki Giannopoulou
- Georgios-Ioannis Poupouzas
- Asimina Chalioti
Institutions
- National and Kapodistrian University of Athens (GR)
- Evangelismos Hospital (GR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-09-09
- DOI
- https://doi.org/10.3389/fendo.2024.1414785
- Citations
- 5
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.93