Canine mesenchymal stem cell-derived exosomes attenuate renal ischemia-reperfusion injury through miR-146a-regulated macrophage polarization
These findings suggest that miR-146a plays a significant role in facilitating the transition of LPS-induced macrophages from M1 to M2 phenotype. As a result, the modulation of macrophage polarization by ADMSC-Exos is achieved via the encapsulation and conveyance of miR-146a, leading to diminished infiltration of inflammatory cells in renal tissue and mitigation of the inflammatory reaction following canine renal IR.
Authors
- Haocheng Huang (ORCID: https://orcid.org/0000-0002-9782-203X)
- Hongchuan Deng
- Jiahui Cao
- Ziyao Zhou (ORCID: https://orcid.org/0000-0002-5484-5442)
- Dechun Chen (ORCID: https://orcid.org/0000-0002-4339-3778)
- Haifeng Liu (ORCID: https://orcid.org/0000-0002-7495-9332)
- Zhijun Zhong (ORCID: https://orcid.org/0009-0003-1071-7160)
- Guangneng Peng
- Xinmiao Wang (ORCID: https://orcid.org/0009-0001-5075-6573)
Institutions
- Sichuan Agricultural University (CN)
- Southwest Minzu University (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2024-09-09
- DOI
- https://doi.org/10.3389/fvets.2024.1456855
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Sichuan Province