8-weeks aerobic exercise ameliorates cognitive deficit and mitigates ferroptosis triggered by iron overload in the prefrontal cortex of APPSwe/PSEN1dE9 mice through Xc−/GPx4 pathway
8 weeks aerobic exercise can improve learning and memory abilities in AD, upregulate GPx4/Xc<sup>-</sup> pathway in PFC to reduce ferroptosis induced by AD.
Authors
- Xinyuan Zhu (ORCID: https://orcid.org/0000-0002-2891-837X)
- Guoliang Fang (ORCID: https://orcid.org/0000-0001-5864-9687)
- Chaoyang Li (ORCID: https://orcid.org/0000-0003-3582-4141)
- Qiong Yang (ORCID: https://orcid.org/0000-0002-3658-1375)
- Shufan Wang
- Kaiyin Cui
Institutions
- Netaji Subhas National Institute of Sports (IN)
- China Institute of Sport Science (CN)
- Beijing Sport University (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2024-09-09
- DOI
- https://doi.org/10.3389/fnins.2024.1453582
- Citations
- 14
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 5.87
Funders
- National Natural Science Foundation of China