Emapalumab Treatment in Patients With Rheumatologic Disease–Associated Hemophagocytic Lymphohistiocytosis in the United States: A Retrospective Medical Chart Review Study
Emapalumab-containing regimens stabilized or normalized most key laboratory parameters, reduced glucocorticoid dose, and were associated with low disease-related mortality, thereby demonstrating potential benefits in patients with rheumatologic disease-associated HLH.
Authors
- Michelle L. Hermiston (ORCID: https://orcid.org/0000-0003-1790-2679)
- Susmita N. Sarangi (ORCID: https://orcid.org/0000-0001-5626-4759)
- Carl E. Allen (ORCID: https://orcid.org/0000-0002-6625-739X)
- Mona Riskalla (ORCID: https://orcid.org/0000-0002-3591-3841)
- Abiola Oladapo (ORCID: https://orcid.org/0000-0001-6222-2491)
- Renee Modica (ORCID: https://orcid.org/0000-0001-5250-759X)
- John Carter (ORCID: https://orcid.org/0000-0001-7395-0398)
- Anand Tandra
- Lauren Draper
- Adi Zoref‐Lorenz (ORCID: https://orcid.org/0000-0002-9837-4427)
- May Chien
- Michael S. Isakoff (ORCID: https://orcid.org/0000-0003-4790-9919)
- Deepika Bhatla
- Shanmuganathan Chandrakasan (ORCID: https://orcid.org/0000-0001-8007-9932)
- Sachit Patel
- J. Allyson Hays
- Kelly Walkovich
- Michael B. Jordan (ORCID: https://orcid.org/0000-0003-4207-3542)
- Prakash Satwani (ORCID: https://orcid.org/0000-0003-3867-9066)
- Rabi Hanna (ORCID: https://orcid.org/0000-0001-7518-309X)
- Priti Pednekar (ORCID: https://orcid.org/0000-0002-0543-6677)
- Taizo A. Nakano (ORCID: https://orcid.org/0000-0003-0389-2297)
- Edward M. Behrens (ORCID: https://orcid.org/0000-0002-4603-7963)
- Patricia M. Hobday (ORCID: https://orcid.org/0000-0002-6412-8981)
- Olive S. Eckstein (ORCID: https://orcid.org/0000-0002-1895-8810)
- Jennifer W. Leiding (ORCID: https://orcid.org/0000-0002-7573-9390)
- John Yee
- Ashley P. Hinson
- Robert B. Cooper
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Cleveland Clinic (US)
- Children's Mercy Hospital (US)
- Lucile Packard Children's Hospital (US)
- Children's Hospital of Philadelphia (US)
- NewYork–Presbyterian Hospital (US)
- Johns Hopkins University (US)
- Emory University (US)
- Tel Aviv University (IL)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- Georgetown University (US)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- University of Florida Health (US)
- Texas Health Dallas (US)
- New York Hospital Queens (US)
- Meir Medical Center (IL)
- Flower Hospital (US)
- MedStar Georgetown University Hospital (US)
- Children's Hospital Colorado (US)
- Johns Hopkins All Children's Hospital (US)
- Franciscan Health Indianapolis (US)
- Connecticut Children's Medical Center (US)
- Aflac (United States) (US)
- Precision for Medicine (United States) (US)
- Mercy Hospital (US)
- Levine Children's Hospital (US)
- University of Minnesota Medical Center (US)
- Children's Healthcare of Atlanta (US)
- Saint Louis University (US)
- University of Nebraska Medical Center (US)
- University of Florida Health Science Center (US)
- University of Cincinnati (US)
- University of Cincinnati Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1002/art.42985
- Citations
- 15
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 6.82
Funders
- Swedish Orphan Biovitrum