Improved health by combining dietary restriction and promoting muscle growth in DNA repair‐deficient progeroid mice
In muscle, we found synergistic effects of combining sActRIIB with DR, but not in kidney, with an overall better health in the double intervention group. Crucially, the benefits of each single intervention are not lost when administered in combination, but rather strengthened, even when sActRIIB was applied late in life, opening opportunities for translation to human.
Authors
- Renata M. C. Brandt (ORCID: https://orcid.org/0000-0003-0514-5623)
- Dick Jaarsma (ORCID: https://orcid.org/0000-0002-0519-2940)
- Yvonne Rijksen
- Olli Ritvos (ORCID: https://orcid.org/0000-0001-7017-6931)
- Ivar van Galen
- Ketan Patel (ORCID: https://orcid.org/0000-0002-7131-749X)
- Daphne S. J. Komninos (ORCID: https://orcid.org/0000-0002-3893-3389)
- Lisanne J. van’t Sant (ORCID: https://orcid.org/0000-0003-3133-599X)
- María B. Birkisdóttir (ORCID: https://orcid.org/0000-0003-1184-5255)
- Wilbert P. Vermeij (ORCID: https://orcid.org/0000-0002-9690-1385)
- Khalid Alyodawi (ORCID: https://orcid.org/0000-0001-5084-0743)
- Kimberly Smit (ORCID: https://orcid.org/0000-0002-6702-4045)
- Jennie L. von der Heide
- Tobias B. Huber (ORCID: https://orcid.org/0000-0001-7175-5062)
- Sander Barnhoorn
- Rutger A. Ozinga
- Oliver Kretz
- Sathivel Vaiyapuri
Institutions
- University of Helsinki (FI)
- Universität Hamburg (DE)
- Erasmus MC (NL)
- University of Wasit (IQ)
- University Medical Center Hamburg-Eppendorf (DE)
- Oncode Institute (NL)
- Princess Máxima Center (NL)
- Erasmus MC Cancer Institute (NL)
- University of Reading (GB)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2024-09-08
- DOI
- https://doi.org/10.1002/jcsm.13570
- Citations
- 4
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Deutsche Forschungsgemeinschaft
- ZonMw
- Bundesministerium für Bildung und Forschung
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Bundesministerium für Bildung und Frauen