Involvement of different K<sup>+</sup> channel subtypes in hydrogen sulfide‐induced vasorelaxation of human internal mammary artery
Our results demonstrated that H<sub>2</sub>S donor, NaHS, induced concentration-dependent relaxation of isolated HIMA. Vasorelaxant mechanisms of H<sub>2</sub>S included direct or indirect opening of different K<sup>+</sup> channel subtypes, K<sub>ATP</sub>, BK<sub>Ca</sub>, SK<sub>Ca</sub>/IK<sub>Ca</sub>, and K<sub>V</sub> (subtype K<sub>V</sub>1.3), in addition to NO pathway activation and interference with extracellular Ca<sup>2+</sup> influx.
Authors
- Guo‐Wei He (ORCID: https://orcid.org/0000-0001-6497-876X)
- Predrag Milojević
- Marija Marinko (ORCID: https://orcid.org/0000-0001-9150-7381)
- Qin Yang (ORCID: https://orcid.org/0000-0002-9792-4431)
- Vladimir Kanjuh
- Aleksandra Novaković (ORCID: https://orcid.org/0000-0002-1693-8234)
- Ivan Stojanović (ORCID: https://orcid.org/0000-0002-6030-1804)
- Dragoslav Nenezić
Institutions
- Serbian Academy of Sciences and Arts (RS)
- Oregon Health & Science University (US)
- TEDA International Cardiovascular Hospital (CN)
- University of Belgrade (RS)
- Institute for Cardiovascular Diseases of Vojvodina (RS)
Publication Details
- Journal
- Fundamental and Clinical Pharmacology
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1111/fcp.13036
- Citations
- 2
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.59