Microvascular and cellular dysfunctions in Alzheimer’s disease: an integrative analysis perspective

Alzheimer's disease (AD) is the most common cause of dementia, characterized by memory loss, cognitive decline, personality changes, and various neurological symptoms. The role of blood-brain barrier (BBB) injury, extracellular matrix (ECM) abnormalities, and oligodendrocytes (ODCs) dysfunction in AD has gained increasing attention, yet the detailed pathogenesis remains elusive. This study integrates single-cell sequencing of AD patients' cerebrovascular system with a genome-wide association analysis. It aims to elucidate the associations and potential mechanisms behind pericytes injury, ECM disorder, and ODCs dysfunction in AD pathogenesis. Finally, we identified that abnormalities in the pericyte PI3K-AKT-FOXO signaling pathway may be involved in the pathogenic process of AD. This comprehensive approach sheds new light on the complex etiology of AD and opens avenues for advanced research into its pathogenesis and therapeutic strategies.

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Publication Details

Journal
Scientific Reports
Published
2024-09-09
DOI
https://doi.org/10.1038/s41598-024-71888-0
Citations
9
Primary Topic
Barrier Structure and Function Studies
Type
article
Field-Weighted Citation Impact
2.23

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article

Microvascular and cellular dysfunctions in Alzheimer’s disease: an integrative analysis perspective

Chunyan Zuo, Yuanyuan Liang, Changhe Shi, Mengnan Guo et al.
9 citations
Scientific Reports
Barrier Structure and Function Studies
2.23
article

Microvascular and cellular dysfunctions in Alzheimer’s disease: an integrative analysis perspective

Chunyan Zuo, Yuanyuan Liang, Changhe Shi, Mengnan Guo, Jie Tian, Mengjie Li, Jingjing Shi, Zhengwei Hu, Xiaoyan Hao, Shuangjie Li, Chengyuan Mao, Yuming Xu, Mibo Tang, Dongrui Ma
article en
9 citations

Abstract

Alzheimer's disease (AD) is the most common cause of dementia, characterized by memory loss, cognitive decline, personality changes, and various neurological symptoms. The role of blood-brain barrier (BBB) injury, extracellular matrix (ECM) abnormalities, and oligodendrocytes (ODCs) dysfunction in AD has gained increasing attention, yet the detailed pathogenesis remains elusive. This study integrates single-cell sequencing of AD patients' cerebrovascular system with a genome-wide association analysis. It aims to elucidate the associations and potential mechanisms behind pericytes injury, ECM disorder, and ODCs dysfunction in AD pathogenesis. Finally, we identified that abnormalities in the pericyte PI3K-AKT-FOXO signaling pathway may be involved in the pathogenic process of AD. This comprehensive approach sheds new light on the complex etiology of AD and opens avenues for advanced research into its pathogenesis and therapeutic strategies.

Scientific ReportsVol. 14(1)
Zhengzhou University (CN), Zhengzhou Railway Vocational & Technical College (CN), First Affiliated Hospital of Zhengzhou University (CN)
National Natural Science Foundation of China, Zhengzhou University, First Affiliated Hospital of Zhengzhou University
Zero hunger
Openalex Percentile: Top 12%
Barrier Structure and Function Studies
2.23
DOIOpen Access PDFOpenAlex
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