Oxidative Stress in the Murine Model of Extraparenchymal Neurocysticercosis
Oxidative stress is associated with several infectious diseases, as well as the severity of inflammatory reactions. The control of inflammation during parasite destruction is a target of neurocysticercosis treatment, as inflammation is strongly related to symptom severity. In this study, we investigated the presence of malondialdehyde and protein carbonyl, two by-products of reactive oxygen species (ROS), in an experimental model of extraparenchymal neurocysticercosis. Twenty male and twenty female rats were inoculated with 50 cysts of <i>Taenia crassiceps</i> in the subarachnoid space of the cisterna magna. Ten animals (five males and five females) were used as controls. Three months after inoculation, their brains were harvested for oxidative stress and histological assessments. Infected animals had higher scores for inflammatory cell infiltrates, malondialdehyde, and protein carbonyl. These results encourage future efforts to monitor oxidative stress status in neurocysticercosis, particularly in the context of controlling inflammation.
Authors
- Marco Antônio Zanini (ORCID: https://orcid.org/0000-0002-5712-9783)
- Diego Generoso (ORCID: https://orcid.org/0000-0003-4486-5594)
- Sabrina Setembre Batah (ORCID: https://orcid.org/0000-0002-9694-3489)
- Camila Renata Corrêa (ORCID: https://orcid.org/0000-0001-8493-5329)
- Edda Sciutto (ORCID: https://orcid.org/0000-0001-5608-5355)
- Alexandre Todorovic Fabro (ORCID: https://orcid.org/0000-0002-7687-3161)
- Manuella Pacífico de Freitas Segredo
- Pedro Tadao Hamamoto Filho (ORCID: https://orcid.org/0000-0001-6436-9307)
- Tatiane de Camargo Martins (ORCID: https://orcid.org/0000-0002-6006-014X)
- Agnès Fleury (ORCID: https://orcid.org/0000-0002-8930-2202)
Institutions
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Universidade Estadual Paulista (Unesp) (BR)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Microorganisms
- Published
- 2024-09-08
- DOI
- https://doi.org/10.3390/microorganisms12091860
- Citations
- 1
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico