EP406 - Exploring the Nexus: Serum Fluoride, Lipid Profiles, and Gallstone Formation in a Cross-Sectional Study

Abstract Objectives Assessing and comparing serum fluoride and lipid profiles in individuals with gallstones and in healthy controls. Investigating the correlation between serum fluoride levels and lipid profiles specifically in gallstone cases. Estimating concentrations of fluoride, cholesterol, triglycerides, bilirubin, calcium, and magnesium in gallstones. Methods This cross-sectional study recruited twenty-five gallstone patients seeking evaluation and treatment at the General Surgery department over a two-month period. Twenty-five age- and gender-matched controls were enrolled using purposive sampling. Results Our findings revealed that, regardless of age group (26-70), individuals with higher serum lipid levels and gallstones exhibited fluoride levels in the gallstones ranging from 0.5 to 1 PPM, suggesting a positive impact of fluoride on gallstones. Notably, calcium and uric acid levels were significantly elevated, measuring 19 and 14 mg per gram, respectively. These finding prompts clinicians to consider the independent role of fluoride in regions with higher exposure and chronicity. Conclusion Our study uncovered a positive correlation between elevated serum lipid levels and gallstones, highlighting fluoride concentrations in gallstones ranging from 0.5-1 PPM. Increased calcium and uric acid levels, particularly in regions of heightened exposure, point to fluoride's independent role in gallstone formation. Patients with gallstones showed heightened lipid levels, positioning fluoride as an influential factor. Notably, cations like calcium and magnesium, alongside non-protein substances such as uric acid, displayed stronger associations with gallstones, with negligible gender-based differences. These findings offer clinicians valuable insights, underscoring the potential significance of fluoride and related factors in understanding and addressing gallstone disease.