Chromosomal instability is associated with prognosis and efficacy of bevacizumab after resection of colorectal cancer liver metastasis
Our study showed that high chromosomal instability is a negative prognostic factor for patients with initially resectable CRLM after liver resection. CIN may have positive correlations with angiogenesis through expression of IL-6-VEGFA axis and be used as a potential predictor of efficacy of bevacizumab.
Authors
- Qingjian Ou (ORCID: https://orcid.org/0000-0002-6881-8680)
- Rong Yang (ORCID: https://orcid.org/0000-0002-6112-3149)
- Xiaojun Wu (ORCID: https://orcid.org/0000-0001-8737-6286)
- Jiayu Wang (ORCID: https://orcid.org/0000-0003-1967-389X)
- Jiahua He (ORCID: https://orcid.org/0000-0002-9075-4978)
- Binyi Xiao (ORCID: https://orcid.org/0000-0002-7675-3207)
- Wenhua Fan
- Lan Jin (ORCID: https://orcid.org/0000-0001-5702-0182)
- Zhizhong Z. Pan (ORCID: https://orcid.org/0000-0002-4022-8750)
- Weihao Li (ORCID: https://orcid.org/0000-0003-4593-4264)
- Chi Zhou (ORCID: https://orcid.org/0000-0002-8736-6501)
- Junzhong Lin
- Yujing Fang
- Jianhong Peng
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- State Key Laboratory of Oncology in South China
Publication Details
- Journal
- Annals of Medicine
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1080/07853890.2024.2396559
- Citations
- 4
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Natural Science Foundation of Guangdong Province