Genetic Variance in Heparan Sulfation Is Associated With Salt Sensitivity
The C allele of rs2892799 in <i>NDST3</i> exhibits higher BP in high sodium conditions when compared with low sodium conditions, whereas no differences were detected for the T allele. Concomitantly, both alleles demonstrate distinct expressions of D0S0, which, in turn, correlates with sodium-mediated BP elevation. These findings underscore the potential significance of genetic glycosaminoglycan variation in human BP regulation.
Authors
- Rik Olde Engberink (ORCID: https://orcid.org/0000-0002-3177-2279)
- Bert‐Jan H. van den Born (ORCID: https://orcid.org/0000-0003-0943-4393)
- Bart Ferwerda (ORCID: https://orcid.org/0000-0002-7050-5931)
- Liffert Vogt (ORCID: https://orcid.org/0000-0002-4585-7505)
- Aeilko H. Zwinderman (ORCID: https://orcid.org/0000-0003-0361-3139)
- Jetta J. Oppelaar (ORCID: https://orcid.org/0000-0003-3528-4886)
- Henrike Galenkamp (ORCID: https://orcid.org/0000-0002-5904-3465)
- S. Matthijs Boekholdt (ORCID: https://orcid.org/0000-0002-0861-0765)
- Mohamed Romman
- Ghazalah Sahebdin
Institutions
- United States Nuclear Regulatory Commission (US)
- John Benjamins Publishing Company (Netherlands) (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Hypertension
- Published
- 2024-09-09
- DOI
- https://doi.org/10.1161/hypertensionaha.124.23421
- Citations
- 7
- Primary Topic
- Sodium Intake and Health
- Type
- article
- Field-Weighted Citation Impact
- 2.17
Funders
- Wellcome Trust
- Cancer Research UK
- British Heart Foundation
- European Commission
- ZonMw
- Hartstichting
- Nierstichting
- Northwest Regional Development Agency
- Medical Research Council