Antibody responses to common viruses according to COVID‐19 severity and postacute sequelae of COVID‐19
Limited research suggests that certain viruses reactivate in severe-acute-respiratory-syndrome-coronavirus 2 infection, contributing to the development of postacute sequelae of COVID-19 (PASC). We examined 1083 infected individuals from a population-based cohort, and assessed differences in plasma immunoglobulin (Ig)G and immunoglobulin A levels against Epstein-Barr virus (EBV), cytomegalovirus, varicella zoster virus (VZV), BK polyomavirus, KI polyomavirus, WU polyomavirus (WUPyV), respiratory syncytial virus, and Adv-36 according to the severity of previous COVID-19 and PASC history. Individuals who had experienced severe COVID-19 had higher antibody responses to latent viruses. Ever PASC, active persistent PASC, and PASC with neuropsychiatric symptoms were associated with higher immnoglobulin G to EBV early antigen-diffuse, VZV, and WUPyV even among individuals without previous severe COVID-19.
Authors
- Marc Bañuls
- Otávio T. Ranzani (ORCID: https://orcid.org/0000-0002-4677-6862)
- Marta Vidal (ORCID: https://orcid.org/0000-0001-6891-7032)
- Eva Alonso Nogués
- Manolis Kogevinas (ORCID: https://orcid.org/0000-0002-9605-0461)
- Susana Iraola‐Guzmán (ORCID: https://orcid.org/0000-0003-3359-1241)
- Alfons Jiménez (ORCID: https://orcid.org/0000-0003-0301-3344)
- Judith García‐Aymerich (ORCID: https://orcid.org/0000-0002-7097-4586)
- Gemma Moncunill (ORCID: https://orcid.org/0000-0001-5105-9836)
- Ruth Aguilar (ORCID: https://orcid.org/0000-0003-3277-3107)
- Rafael de Cid (ORCID: https://orcid.org/0000-0003-3579-6777)
- Ana Espinosa (ORCID: https://orcid.org/0000-0001-7399-3267)
- Marianna Karachaliou (ORCID: https://orcid.org/0000-0002-3014-0747)
- Gemma Castaño‐Vinyals (ORCID: https://orcid.org/0000-0003-4468-1816)
- Carlota Dobaño (ORCID: https://orcid.org/0000-0002-6751-4060)
Institutions
- Universitat Pompeu Fabra (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Hospital Del Mar (ES)
- Municipal Institute for Medical Research (ES)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Barcelona Institute for Global Health (ES)
- Banc de Sang i Teixits (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Hospital del Mar Research Institute (ES)
Publication Details
- Journal
- Journal of Medical Virology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/jmv.29862
- Citations
- 6
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- Ministerio de Ciencia e Innovación
- Fundació Privada Daniel Bravo Andreu
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación