<i>FGFR</i> Alterations in Thyroid Carcinoma: A Novel Class of Primary Drivers with Significant Therapeutic Implications and Secondary Molecular Events Potentially Mediating Resistance in Thyroid Malignancy
Introduction: Diagnostic classification of thyroid malignancy is primarily accomplished through examination of histomorphological features and may be substantiated and clarified by molecular data.1–3 Individual molecular drivers show relatively robust and specific associations with histological subtypes of thyroid malignancy, including BRAF sequence variants and kinase gene fusions in papillary thyroid carcinoma, predominantly RAS variants in follicular-patterned neoplasia,4 and additional “late” mutations affecting TERT promoter, TP53, and the PI3K/AKT/PTEN pathway in high-grade malignancies.5,6 Given the oncogenic role of FGFR, particularly FGFR1-3,7,8 the goal of this study was to explore the role of FGFR in thyroid carcinoma biology.
Authors
- Bayan Alzumaili (ORCID: https://orcid.org/0000-0001-5628-6384)
- Mark F Sabbagh (ORCID: https://orcid.org/0000-0003-1996-5251)
- A. John Iafrate
- Lori J. Wirth (ORCID: https://orcid.org/0000-0002-2629-2289)
- Vânia Nosé (ORCID: https://orcid.org/0000-0002-3934-6610)
- Brennan Decker
- Tyler Janovitz
- Peter M. Sadow (ORCID: https://orcid.org/0000-0003-1036-6367)
- Adam S. Fisch (ORCID: https://orcid.org/0000-0002-4742-8165)
- Stephanie Siegmund (ORCID: https://orcid.org/0000-0003-1848-2389)
- William C. Faquin (ORCID: https://orcid.org/0000-0002-9043-7171)
- Jochen K. Lennerz (ORCID: https://orcid.org/0000-0003-2434-4978)
- Justine A. Barletta (ORCID: https://orcid.org/0000-0002-7167-4358)
- Valentina Nardi (ORCID: https://orcid.org/0000-0002-0486-416X)
- Long P. Le (ORCID: https://orcid.org/0000-0003-4212-6528)
- Dora Dias-Santagata
- Gregory W. Randolph
Institutions
- Brigham and Women's Hospital (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Foundation Medicine (United States)
Publication Details
- Journal
- VideoEndocrinology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1089/ve.2024.0016
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00